TRANsCre-DIONE Transdifferentiates Scar-Forming Reactive Astrocytes Into Functional Motor Neurons

Researchers created TRANsCre-DIONE, a dual-promoter split-Cre system combining GFAP and Lcn2 regulatory elements with Cre-dependent Neurog2 expression under the EF1α promoter, enabling selective targeting of scar-forming reactive astrocytes.