ALDH1A1 Overexpression in Melanoma Cells Promotes Tumor Angiogenesis by Activating the IL-8/Notch Signaling Cascade

In a 3D multicellular system, obtained co‑culturing melanoma cancer cells with stromal cells, including ECs, melanoma ALDH1A1 overexpression induced the recruitment of ECs into the core of the tumorspheres.