Inhibition of USP14 Enhances Anti-tumor Effect in Vemurafenib-Resistant Melanoma by Regulation of Skp2

In vitro, the effect of the combination regimen of vemurafenib and b-AP15 on vem-sensitive and vem-resistant melanoma has been investigated by wound healing, colony formation, transwell invasion assay, flow cytometry, lysosome staining, and ROS detection.