RNA Polymerase I Inhibition Induces Terminal Differentiation, Growth Arrest and Vulnerability to Senolytics in Colorectal Cancer Cells

The authors showed that loss of the tumor suppressor adenomatous polyposis coli, which constituted the initiating event in the adenoma carcinoma sequence for colorectal cancer, induced expression of RNA polymerase I transcription machinery and subsequently upregulated ribosomal DNA transcription.