A Mechanosensitive Lipolytic Factor in the Bone Marrow Promotes Osteogenesis and Lymphopoiesis

Mechanistically, reticulocalbin-2 binds to a functional receptor complex, which is composed of neuronilin-2 and integrin beta-1, to activate a cAMP-PKA signaling pathway that mobilizes bone marrow fat via lipolysis to fuel the differentiation and function of mesenchymal and hematopoietic stem cells.