Acute Lymphoblastic Leukemia-Secreted miRNAs Induce a Proinflammatory Microenvironment and Promote the Activation of Hematopoietic Progenitors

Investigators have identified three miRNAs, miR-146a-5p, miR-181b-5p, and miR-199b-3p, as potential candidates for TLR8 ligation, which are overexpressed in acute lymphoblastic leukemia and show agonist functional binding.