Chronologically Modified Androgen Receptor in Recurrent Castration-Resistant Prostate Cancer and Its Therapeutic Targeting

ACK1 kinase–mediated AR Y267 phosphorylation was a prerequisite for AR K609 acetylation, which spawned positive feedback loops at both the transcriptional and posttranslational level that regenerated and sustained high androgen receptor and ACK1 expression.
[Science Translational Medicine]
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