Tumor Metabolite Lactate Promotes Tumorigenesis by Modulating MOESIN Lactylation and Enhancing TGF-β Signaling in Regulatory T Cells

The authors focus on the effects of lactate on Treg cells. In vitro, lactate improved Treg cell stability and function, whereas lactate degradation reduced Treg cell induction, increased antitumor immunity, and decreased tumor growth in mice.