SM22α Cell Specific HIF Stabilization Mitigates Hyperoxia-Induced Neonatal Lung Injury

Scientists determined whether hypoxia-inducible factors (HIF) stabilization in SM22α expressing cells mitigated hyperoxia-induced neonatal lung injury. They crossed SM22α-promotor-driven Cre recombinase mice with prolyl hydroxylase (PHD) PHD1flox/flox and PHD2flox/flox mice.