Increased Susceptibility of Irradiated Mice to Aspergillus fumigatus Infection via NLRP3/GSDMD Pathway in Pulmonary Bronchial Epithelia

A mouse model of Aspergillus fumigatus infection after radiation was established by irradiating with 5 Gy on the chest and instilling 5 × 107/ml Aspergillus fumigatus conidia into trachea after 24 h to explore the effect and study its function and mechanism.