Designed miR-19a/B Sponge Induces Apoptosis in Lung Cancer Cells Through the PI3K-PTEN-Akt Pathway Regulation

Investigators designed an miR-19a/b sponge plasmid and transfected it into A549 lung cancer cell lines and analyzed its effects on PTEN and TP53INP1 gene expression as the main miR-19a/b target and apoptosis rate in these cell lines.