Phenotypic Screening With Deep Learning Identifies HDAC6 Inhibitors As Cardioprotective in a BAG3 Mouse Model of Dilated Cardiomyopathy

To identify candidate therapeutics, scientists developed an in vitro dilated cardiomyopathy model using induced pluripotent stem cell-derived cardiomyocytes deficient in B-cell lymphoma 2-associated athanogene 3 (BAG3).