Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR-Driven Lung Cancer

Flow cytometry and single-cell RNA sequencing of the lung tumors reveal that JHU083 increased CD8+ T cell and CD4+ Th1 cell infiltration, while EVax elicits robust Th1 cell-mediated immune responses and protects mice against EGFRL858R mutation-driven lung tumorigenesis.