Runx3 Drives a CD8⁺ T Cell Tissue Residency Program That Is Absent in CD4⁺ T Cells

The authors showed that, as a direct consequence of this Runx3-deficiency, CD4+ tissue-resident memory T cells (TRM) cells lacked the transforming growth factor-β-responsive transcriptional network that underpins the tissue residency of epithelial CD8+ TRM cells.