Deficiency of Mature B Cells Does Not Alter the Atherogenic Response to Castration in Male Mice

Researchers studied B cell-deficient μMT and genotype control male mice on an atherosclerosis-prone Apoe−/− background that were castrated or sham-operated pre-pubertally and fed a high-fat diet between 8 and 16 weeks of age to accelerate atherosclerosis development.