NewslettersNeural Cell NewsSPTLC1 Variants Associated with ALS Produce Distinct Sphingolipid Signatures through Impaired Interaction with ORMDL ProteinsBy lbeveridge - July 29, 2022094Scientists showed that ORMDL binding to the holoenzyme complex was impaired in cells expressing pathogenic SPTLC1-ALS alleles, resulting in increased sphingolipid synthesis and a distinct lipid signature.[Journal of Clinical Investigation]AbstractFull Article