BET Bromodomain Inhibition Rescues PD-1-Mediated T-cell Exhaustion in Acute Myeloid Leukemia

JQ1 dramatically impaired the expression of programmed cell death receptor-1 (PD-1) and T cell immunoglobulin mucin-domain-containing-3 and promoted the secretion of cytokines in T cells from patients with acute myeloid leukemia.