Tyrosine Kinase Inhibition Alters Intratumoral CD8⁺ T Cell Subtype Composition and Activity

To identify limitations imposed by imatinib on the antitumor immune response, investigators performed bulk RNA sequencing, single-cell RNAseq, and flow cytometry to phenotype CD8+ T cell subsets in a genetically engineered mouse model of gastrointestinal stromal tumor.