SOX15 Transcriptionally Increases the Function of AOC1 To Modulate Ferroptosis and Progression in Prostate Cancer
Investigators discovered that high expression of Amine oxidase copper-containing 1 AOC1 is significantly associated with reduced proliferation and migration in prostate cancer both in vitro and in vivo.
[EMBO Journal] Using a variety of in vitro and in vivo techniques, researchers showed that metastatic prostate cancer cells acquire a specific Na+/Ca2+ signature required for persistent invasion.
[Molecular Cell] Investigators explored the role of minor intron-containing genes and minor spliceosome in cancer, taking prostate cancer as an exemplar.
[Nature Communications] The authors uncovered dual-phosphorylated form of sterol regulatory element-binding protein 1 (SREBF1), pY673/951-SREBF1 that acts as an androgen sensor, and dissociates from androgen receptor in androgen deficient environment, followed by nuclear translocation.