Synthetic Oleanane Triterpenoid Derivative CDDO-Me Disrupts Cellular Bioenergetics To Suppress Pancreatic Ductal Adenocarcinoma via Targeting SLC1A5

The authors verified that methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) downregulated glutamine transporter SLC1A5, resulting in excessive reactive oxygen species levels that suppressed tumor growth.
[Journal of Biochemical and Molecular Toxicology]

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