Synthetic Oleanane Triterpenoid Derivative CDDO-Me Disrupts Cellular Bioenergetics To Suppress Pancreatic Ductal Adenocarcinoma via Targeting SLC1A5

The authors verified that methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) downregulated glutamine transporter SLC1A5, resulting in excessive reactive oxygen species levels that suppressed tumor growth.