Chromosome Silencing In Vitro Reveals Trisomy 21 Causes Cell-Autonomous Deficits in Angiogenesis and Early Dysregulation in Notch Signaling

To understand which cell types and pathways are more directly affected by trisomy 21 (T21), the authors used an inducible-XIST system to silence one chromosome 21 in vitro. T21 caused the dysregulation of Notch signaling in iPSCs, potentially affecting cell-type programming.