Induced Pluripotent Stem Cells Display a Distinct Set of MHC I-Associated Peptides Shared by Human Cancers

The authors characterized the MHC I-associated peptide (MAP) repertoire of hiPSCs using proteogenomics. Their analyses revealed a set of 46 pluripotency-associated MAPs (paMAPs) absent from the transcriptome of normal tissues and adult stem cells but expressed in PSCs and multiple adult cancers.