Fenretinide Combines Perturbation of Signaling Kinases, Cell-Extracellular Matrix Interactions and Matrix Metalloproteinase Activation to Inhibit Invasion in Oral Squamous Cell Carcinoma Cells

Scientists elucidated fenretinide’s effects on additional invasion-relevant mechanisms including matrix metalloproteinase activation and function, cell-ECM attachments, and interaction with a kinase that was essential for the epithelial-myoepithelial transformation i.e. c-Jun NH2-terminal kinase.