The Negative Regulation of Gene Expression by MicroRNAs as Key Driver of Inducers and Repressors of Cardiomyocyte Differentiation

Researchers reviewed the mechanisms of cardiomyocyte (CM) differentiation during development and from regenerative stem cells with a focus on the involvement of microRNAs in the process, putting in perspective their negative gene regulation as a main modifier of effective CM regeneration in the adult heart.