Temporal Control of PDGFRα Regulates the Fibroblast-to-Myofibroblast Transition in Wound Healing

Elevated platelet-derived growth factor receptor α (PDGFRα) signaling increased proliferation but unexpectedly delayed the fibroblast-to-myofibroblast transition, suggesting that PDGFRα must be downregulated for myofibroblast differentiation.