Cross-Talk between IL-6 Trans-signaling and AIM2 Inflammasome/IL-1β Axes Bridge Innate Immunity and Epithelial Apoptosis to Promote Emphysema

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Scientists investigated whether innate immune inflammasome complexes, comprising the adaptor ASC, Caspase-1 and specific pattern recognition receptors, promoted the pathogenesis of emphysema.
[Proceedings of the National Academy of Sciences of the United States of America]
Abstract