The Phagosomal Solute Transporter SLC15A4 Promotes Inflammasome Activity via mTORC1 Signaling and Autophagy Restraint in Dendritic Cells

Scientists showed that in murine dendritic cells the lysosomal histidine/peptide solute carrier transporter SLC15A4, associated with human inflammatory disorders, was recruited to phagosomes and is required for optimal inflammasome activity after infectious or sterile stimuli.