Engineering T Cells to Suppress Acute GvHD and Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation

Researchers showed that OX40 was upregulated on T cells infiltrating graft-versus-host disease (GvHD) target organs in a rhesus macaque model, supporting the hypothesis that targeted ablation of OX40+ T cells will mitigate GvHD pathogenesis.