Specific Inhibition of the Transporter MRP4/ABCC4 Affects Multiple Signaling Pathways and Thrombus Formation in Human Platelets

Transport assays in isolated membrane vesicles showed a concentrationdependent inhibition of MRP4-mediated transport of cyclic nucleotides, thromboxane (Tx)B2 and fluorescein (FITC)- labeled sphingosine-1-phosphate (S1P) by the selective MRP4 inhibitor Ceefourin-1.