Impact of Mesenchymal Stromal Cell-Derived Vesicular Cargo on B-Cell Acute Lymphoblastic Leukemia Progression

Investigators showed that bone marrow microenvironment (BMM)-deficiency of pleckstrin homology domain family M member 1 accelerated murine BCR-ABL1+ B-cell acute lymphoblastic leukemia via regulation of the cargo of small extracellular vesicles released by BMM-derived MSC.