Human TKTL1 Implies Greater Neurogenesis in Frontal Neocortex of Modern Humans than Neanderthals

Using overexpression in developing mouse and ferret neocortex, knockout in fetal human neocortical tissue, and genome-edited cerebral organoids, scientists found that the modern human variant, human Transketolase-like 1 (TKTL1), but not the Neanderthal variant, increases the abundance of basal radial glia but not that of intermediate progenitors