Trafficking between Clonally Related Peripheral T Helper Cells and Tissue-Resident T Helper Cells in Chronic GVHD

Adoptive transfer experiments showed that tissue-resident T helper (Trh) cells from graft-versus-host-disease (GVHD) target tissues gave rise to peripheral T helper (Tph) cells in the blood, and conversely, Tph cells from the blood gave rise to Trh cells in GVHD target tissues.