The Acid Ceramidase/Ceramide Axis Controls Parasitemia in Plasmodium yoelii-Infected Mice by Regulating Erythropoiesis

Researchers used Ac-deficient mice with ubiquitously increased ceramide levels to elucidate the role of endogenous Ac activity in a murine malaria model. Ablation of Ac les to alleviated parasitemia associated with decreased T cell responses in the early phase of Plasmodium yoelii infection.