ELANE Promotes M2 Macrophage Polarization by Down-Regulating PTEN and Participates in the Lung Cancer Progression

The effects of neutrophil elastase (ELANE)-mediated M2 macrophages on lung cancer cell proliferation, migration, and invasion and tumor growth were investigated by in vitro and in vivo experiments after co-culture of macrophage conditioned medium and lung cancer cell lines A549 and H1299.