Dendritic Cell-Derived IL-27 p28 Regulates T Cell Program in Pathogenicity and Alleviates Acute Graft-Versus-Host Disease

Utilizing mice with IL-27 p28 deficiency in dendritic cells, scientists demonstrated that IL-27 p28 deficiency resulted in impaired Treg cell function and enhanced effector T cell responses, corresponding to aggravated acute graft-versus-host disease in mice.