Intra-Tumor Heterogeneity of Cancer Stem Cell-Related Genes and Their Potential Regulatory microRNAs in Metastasizing Colorectal Carcinoma
Scientists provide evidence that expression of cancer stem cell‑related genes and their potential regulatory miRNAs contribute to intra‑tumor heterogeneity in colorectal carcinoma, lymph node, and liver metastasis.
[Science Advances] Scientists used single-nucleus RNA sequencing to characterize a mouse model that mimicked human nonalcoholic steatohepatitis (NASH)–driven HCC, the MUP-uPA mouse fed a high-fat diet.
[JHEP Reports] Mouse liver perfusion was used to identify the effects of interstitial flow on hepatocyte proliferation ex vivo. Isolated hepatocytes in vitro were further exposed to varied shear stresses directly.
[JHEP Reports] Cholangiocarcinoma (CCA) tumor microenvironment was recapitulated on a microfluidic three-channel chip using primary CCA cells, cancer-associated fibroblasts, endothelial cells, and T cells isolated from CCA specimens.