Dysregulated Stem Cell Niches and Altered Lymphocyte Recirculation Cause B and T Cell Lymphopenia in WHIM Syndrome

Using a CXCR4 R334X gain-of-function mouse model of WHIM syndrome, scientists showed that lymphopoiesis is reduced because of a dysregulated mesenchymal stem cell transcriptome characterized by a switch from an adipogenic to an osteolineage-prone program with limited lymphopoietic activity.