Selected Commensals Educate the Intestinal Vascular and Immune System for Immunocompetence

While the immature colon of C. rodentium-infected germ-free mice did not allow sufficient extravasation of neutrophils into the gut lumen, colonization with OMM12 + MC2 commensals initiated the expansion and activation of the visceral vascular system enabling granulocyte transmigration into the gut lumen for effective pathogen elimination.