Iron Regulatory Protein (IRP)–Mediated Iron Homeostasis Is Critical for Neutrophil Development and Differentiation in the Bone Marrow

Scientists reporedt that global disruption of both IRP1 and IRP2 in adult mice impaired neutrophil development and differentiation in the bone marrow, yielding immature neutrophils with abnormally high glycolytic and autophagic activity, resulting in neutropenia.