MicroRNA-6838-5p Suppresses the Self-Renewal and Metastasis of Human Liver Cancer Stem Cells through Downregulating CBX4 Expression and Inactivating ERK Signaling

Human hepatocellular carinoma (HCC) cohort analysis indicated that the epigenetic regulator polycomb chromobox homologue 4 (CBX4) was overexpressed in human HCC. Moreover, scientists found that CBX4 expression was significantly higher in CD44+ CD133+Hep3B CSCs.