Neonatal Ketone Body Elevation Regulates Postnatal Heart Development by Promoting Cardiomyocyte Mitochondrial Maturation and Metabolic Reprogramming

While monitoring cardiomyocyte proliferation capacity in mice models lacking 3-hydroxy-3-methylglutaryl-CoA synthase 2, the rate-limiting enzyme of ketogenesis, researchers discovered that neonatal ketone body elevation was a critical regulatory factor for postnatal heart development.