HIV-1 CD4-Binding Site Germline Antibody–Env Structures Inform Vaccine Design

To understand how somatic hypermutations correlate with BG24 neutralization of HIV-1, scientists reported 4.1 Å and 3.4 Å single-particle cryo-EM structures of two inferred germline BG24 precursors complexed with engineered Env-based immunogens lacking CD4bs N-glycans.