Ezh2^Y641F Mutations Co-Operate with Stat3 to Regulate MHC Class I Antigen Processing and Alter the Tumor Immune Response in Melanoma

Researchers found that expression of Ezh2Y641F caused upregulation of a subset of interferon-regulated genes in melanoma cells. Upregulation of these genes was not a direct effect of changes in H3K27me3, but via a non-canonical interaction between Ezh2 and Signal Transducer and Activator of Transcription 3.