SZT2 Maintains Hematopoietic Stem Cell Homeostasis via Nutrient-Mediated mTORC1 Regulation

Researchers presented that seizure threshold 2 (SZT2), a protein required for mTORC1 downregulation upon nutrient deprivation, was critical for HSC homeostasis, where ablation of SZT2 in HSCs decreased the reserve and impaired the repopulating capacity.