IL-1β–Dependent Extravasation of Preexisting Lung-Restricted Autoantibodies during Lung Transplantation Activates Complement and Mediates Primary Graft Dysfunction

Lung-restricted autoantibodies-mediated injury was localized to the transplanted lung and dependent on IL-1β–mediated permeabilization of pulmonary vascular endothelium, which allowed extravasation of antibodies