Srsf2^P95H/+ Co-operates with Loss of TET2 to Promote Myeloid Bias and Initiate a Chronic Myelomonocytic Leukemia-Like Disease in Mice

Based on human cancer genetics, an inducible Srsf2P95H/+ mutant model was crossed with Tet2fl/fl mice to mutate both concomitantly in hematopoietic stem cells.