Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

Scientists found the receptor-binding domain-sortase A-conjugated ferritin nanoparticle induced neutralizing antibodies in non-human primate against pseudoviruses of SARS-CoV and SARS-CoV-2 variants including 614G, Beta, Delta, Omicron BA.1, BA.2, BA.2.12.1, and BA.4/BA.5, and a designed variant with escape mutations, PMS20.