The Notch1/CD22 Signaling Axis Disrupts Treg Cell Function in SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children

Genetic analysis revealed that MIS-C patients were enriched in rare deleterious variants impacting inflammation and autoimmunity pathways, including dominant-negative mutations in the Notch1 regulators NUMB and NUMBL leading to Notch1 upregulation.