Clonal IgA and IgG Autoantibodies from Individuals at Risk for Rheumatoid Arthritis Identify an Arthritogenic Strain of Subdoligranulum

Using dual immunoglobulin A (IgA) and IgG family plasmablast–derived monoclonal autoantibodies obtained from peripheral blood of individuals at risk for rheumatoid arthritis (RA), investigators identified cross-reactivity between RA-relevant autoantigens and bacterial taxa in the closely related families Lachnospiraceae and Ruminococcaceae.