Repurposing Pentamidine Using Hyaluronic Acid-Based Nanocarriers for Skeletal Muscle Treatment in Myotonic Dystrophy

Researchers proposed hyaluronic acid-based nanoparticles as a novel encapsulation strategy to efficiently deliver pentamidine to skeletal muscle cells. In vitro studies on C2C12 myoblasts and myotubes showed an efficient nanoparticles’ internalization with minimal toxicity.